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CK18 was expressed in standard epithelial cells of most organs but absent in normal squamous epithelium. at the least an occasional weak CK18 positivity was witnessed in 90 of 115 (78.3%) tumor styles. large-spread CK18 positivity was found in 37 (31.9%) of tumor entities, such as adenocarcinomas of the lung, prostate, colon and pancreas as well as